Access Denied to Temporary ASP.NET Files
Sometimes, when attempting to debug an ASP.NET Web Service, you’ll get the following error: Access to the path “C:\WINDOWS\Microsoft.NET\Framework\v1.1.4322\Temporary ASP.NET Files_somewhere_” is denied.
This can be caused when you’re attempting to run with non-admin privileges and you’ve configured the ASP.NET worker process to run under your account.
It can also be caused by the Indexing Service, so check that as well.
If you can’t find another way to fix it, just make sure that the “VS Developers” group has full control over the Temporary ASP.NET Files directory.